SCAP and LAMC2

Data Source:
BioGRID (affinity chromatography technology)

		SCAP	LAMC2
Description		SREBF chaperone	laminin subunit gamma 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Refractive error ( 32231278) Triglyceride levels ( 32203549)	Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Low density lipoprotein cholesterol levels ( 32154731) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)
Interacting Genes		5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		22937	3918
HPRD ID		03300	01031
Ensembl ID		ENSG00000114650	ENSG00000058085
Uniprot IDs		B7Z6H0 Q12770	Q13753
PDB IDs
Enriched GO Terms of Interacting Partners?
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