SCAP and SEC24B

Data Source:
BioGRID (pull down)

		SCAP	SEC24B
Description		SREBF chaperone	SEC24 homolog B, COPII coat complex component
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding	SNARE Binding Protein Binding Zinc Ion Binding
	Biological Process	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading	Neural Tube Closure Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Outflow Tract Morphogenesis Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cochlear Nucleus Development Aorta Morphogenesis COPII Vesicle Coating Auditory Receptor Cell Stereocilium Organization Lung Lobe Morphogenesis Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis COPII-coated Vesicle Cargo Loading Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Refractive error ( 32231278) Triglyceride levels ( 32203549)	Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	2 interacting genes: SCAP SEC23A
Entrez ID		22937	10427
HPRD ID		03300	06216
Ensembl ID		ENSG00000114650	ENSG00000138802
Uniprot IDs		B7Z6H0 Q12770	B4DTM6 O95487
PDB IDs			3EH1
Enriched GO Terms of Interacting Partners?
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