MON1B and VPS11

Data Source:
BioGRID (two hybrid)

		MON1B	VPS11
Description		MON1 homolog B, secretory trafficking associated	VPS11 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mon1-Ccz1 Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Vacuole Vesicle-mediated Transport Early Viral Transcription Late Viral Transcription	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Immune response to measles-mumps-rubella vaccine ( 24811271) Metabolite levels ( 23823483) Multisite chronic pain ( 31194737) Number of sexual partners ( 30643258)	Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41	33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS39 VPS45
Entrez ID		22879	55823
HPRD ID		12342	12258
Ensembl ID		ENSG00000103111	ENSG00000160695
Uniprot IDs		B4DKA0 E7EW32 Q6ZR87 Q7L1V2	A0A087WXL6 B7Z879 Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners?
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