CLCA4 and BDKRB2

Data Source:
BioGRID (two hybrid)

		CLCA4	BDKRB2
Description		chloride channel accessory 4	bradykinin receptor B2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Metallopeptidase Activity Metal Ion Binding	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Ion Transmembrane Transport Chloride Transmembrane Transport	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		Stimuli-sensing channels	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases
GWAS			Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		22802	624
HPRD ID		16719	00213
Ensembl ID		ENSG00000016602	ENSG00000168398
Uniprot IDs		Q14CN2	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?
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