ALDOA and ATP6V1E1

Data Source:
HPRD (in vitro, two hybrid)

		ALDOA	ATP6V1E1
Description		aldolase, fructose-bisphosphate A	ATPase H+ transporting V1 subunit E1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Lysosomal Membrane Endosome Cytosol Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting Two-sector ATPase Complex, Catalytic Domain Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Identical Protein Binding Cadherin Binding Fructose Binding	Protein Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism Hydrolase Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Platelet Degranulation Fructose Metabolic Process Gluconeogenesis Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Neutrophil Degranulation Muscle Cell Cellular Homeostasis Protein Homotetramerization Canonical Glycolysis	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Tiludronic acid
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		33 interacting genes: ADRB2 ALDOB ATP6V1E1 BCAT2 CACNA1A CYTH2 DYNLL1 EGFR ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LINC01554 MLH1 MYOC PCNA PIAS4 PLD2 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	14 interacting genes: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H HSPB2 MESD SLC9A3R1 SOS1 TRAF6 XRCC6
Entrez ID		226	529
HPRD ID		00070	00163
Ensembl ID		ENSG00000149925	ENSG00000131100
Uniprot IDs		P04075 V9HWN7	P36543 Q53Y06
PDB IDs		1ALD 2ALD 4ALD 5KY6
Enriched GO Terms of Interacting Partners?
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