FGF8 and FGFR3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		FGF8	FGFR3
Description		fibroblast growth factor 8	fibroblast growth factor receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Transport Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity Chemoattractant Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	MAPK Cascade Branching Involved In Blood Vessel Morphogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Mesonephros Development Neural Plate Morphogenesis Positive Regulation Of Protein Phosphorylation Heart Looping Blood Vessel Remodeling Heart Morphogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Response To Oxidative Stress Gastrulation Motor Neuron Axon Guidance Mesodermal Cell Migration Positive Regulation Of Cell Population Proliferation Gonad Development Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Pallium Development Subpallium Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Forebrain Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Regulation Of Cell Migration Male Genitalia Development Thyroid Gland Development Otic Vesicle Formation Midbrain-hindbrain Boundary Development Dorsal/ventral Axon Guidance Embryonic Heart Tube Development Limb Morphogenesis Embryonic Hindlimb Morphogenesis Aorta Morphogenesis Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Negative Regulation Of Neuron Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Embryonic Neurocranium Morphogenesis Forebrain Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Tissue Development Pharyngeal System Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Bone Development Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Dopaminergic Neuron Differentiation Cell Migration Involved In Mesendoderm Migration Larynx Morphogenesis	MAPK Cascade Skeletal System Development Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Kinase Activity Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Negative Regulation Of Developmental Growth Positive Regulation Of Protein Kinase B Signaling Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways			Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer
Drugs			XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)	Bladder cancer Multiple myeloma Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) CATSHL syndrome
GWAS		General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Systolic blood pressure ( 30578418)	Bladder cancer ( 24163127 20972438) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3	43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3
Entrez ID		2253	2261
HPRD ID		02727	00624
Ensembl ID		ENSG00000107831	ENSG00000068078
Uniprot IDs		A0A087X1S5 A1A515 P55075	P22607 Q0IJ44
PDB IDs		2FDB	1RY7 2LZL 4K33 6LVM 6PNX
Enriched GO Terms of Interacting Partners?
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