F12 and CD93

Data Source:
HPRD (in vitro)

		F12	CD93
Description		coagulation factor XII	CD93 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Phagocytosis Viral Process Macrophage Activation Neutrophil Degranulation Cell-cell Adhesion
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Neutrophil degranulation
Drugs		Zinc Human C1-esterase inhibitor Ethanolamine oleate Conestat alfa Nafamostat Zinc acetate
Diseases		Factor XII deficiency; Hageman factor deficiency Hereditary angioedema
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Blood metabolite ratios ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)
Interacting Genes		16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	23 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 KIR2DL2 KNG1 MBL2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2
Entrez ID		2161	22918
HPRD ID		01992	00396
Ensembl ID		ENSG00000131187	ENSG00000125810
Uniprot IDs		P00748 Q8IZZ5	Q9NPY3
PDB IDs		4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6L63 6QF7 6SZW
Enriched GO Terms of Interacting Partners?
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