CD93 and COL4A2

Data Source:
HPRD (in vitro)

		CD93	COL4A2
Description		CD93 molecule	collagen type IV alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Phagocytosis Viral Process Macrophage Activation Neutrophil Degranulation Cell-cell Adhesion	Angiogenesis Transcription, DNA-templated Aging Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Neutrophil degranulation	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)	Apolipoprotein B levels ( 32203549) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Retinal arteriolar tortuosity ( 31597446) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		23 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 KIR2DL2 KNG1 MBL2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2	24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL
Entrez ID		22918	1284
HPRD ID		00396	00355
Ensembl ID		ENSG00000125810	ENSG00000134871
Uniprot IDs		Q9NPY3	A0A024RDW8 P08572
PDB IDs			1LI1 5NAX 5NB2 6MPX
Enriched GO Terms of Interacting Partners?
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