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EZH2 and PSMB6
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EZH2
PSMB6
Description
enhancer of zeste 2 polycomb repressive complex 2 subunit
proteasome 20S subunit beta 6
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromatin Silencing Complex
Cytoplasm
ESC/E(Z) Complex
Pronucleus
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Protein-lysine N-methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Chromatin DNA Binding
Histone Methyltransferase Activity
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Primary MiRNA Binding
Promoter-specific Chromatin Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Cadherin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Chromatin Organization
Chromatin Silencing At Telomere
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Gliogenesis
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Cardiac Muscle Hypertrophy In Response To Stress
Histone Methylation
Cerebellar Cortex Development
Hippocampus Development
B Cell Differentiation
Response To Estradiol
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Cellular Response To Trichostatin A
Hepatocyte Homeostasis
Regulation Of Circadian Rhythm
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of GTPase Activity
Negative Regulation Of Epidermal Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Cell Development
Rhythmic Process
Negative Regulation Of Striated Muscle Cell Differentiation
Cellular Response To Hydrogen Peroxide
G1 To G0 Transition
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Methylation
Protein Localization To Chromatin
Positive Regulation Of Protein Serine/threonine Kinase Activity
Liver Regeneration
Histone H3-K27 Trimethylation
Positive Regulation Of Dendrite Development
Positive Regulation Of Cell Cycle G1/S Phase Transition
Response To Tetrachloromethane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Tazemetostat
CPI-1205
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Chronotype (
30696823
)
Colorectal or endometrial cancer (
26621817
)
Crohn's disease (
28067908
)
Familial squamous cell lung carcinoma (
29924316
)
Height (
25282103
31562340
)
Inflammatory bowel disease (
28067908
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Interacting Genes
77 interacting genes:
AKT1
AR
ATP1A1
ATP1B1
ATRX
BCL11A
BRCA1
C7orf25
CCDC85B
CDK2
CDK6
CDKN2B-AS1
CEP63
CRY2
DELEC1
DNAJB11
DNMT1
DNMT3A
DNMT3B
E2F6
EED
EHMT1
EPC2
FBXW7
GADD45G
GTF3C1
H1-1
H3-4
H3C1
HDAC1
HOTAIR
JAK2
KAT2B
KLHDC2
KRTAP10-9
LATS2
MAP3K20
MAP3K7
MAPK8IP2
MAPKAPK3
MED1
MELK
MUC1
MYCN
NINL
PFDN1
PHB2
PHF1
PIN4
PJA1
POLA2
PRDM14
PRMT5
PSMB6
RASA1
RBL2
RELA
RELB
RIN3
RPN2
RPS6KA5
SIRT1
SMN1
SMS
SMYD3
SUV39H1
SUZ12
TAF1D
TK1
TNFSF11
TRIM55
TRIM63
USP1
VAV1
WDR61
WSB2
ZMYND11
8 interacting genes:
ERRFI1
EZH2
FBL
NDOR1
PLK1
POMP
PSMA6
PSMB7
Entrez ID
2146
5694
HPRD ID
03342
02630
Ensembl ID
ENSG00000106462
ENSG00000142507
Uniprot IDs
A0A090N8E9
Q15910
S4S3R8
A0A087X2I4
P28072
Q6IAT9
PDB IDs
2C6V
4MI0
4MI5
5GSA
5H14
5H15
5H17
5H19
5H24
5H25
5HYN
5IJ7
5IJ8
5LS6
5U5T
5U62
5WG6
5WUK
6C23
6C24
6P5L
6U4Y
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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