EZH2 and DNMT3A

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EZH2	DNMT3A
Description		enhancer of zeste 2 polycomb repressive complex 2 subunit	DNA methyltransferase 3 alpha
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Cytoplasm ESC/E(Z) Complex Pronucleus	Chromosome, Centromeric Region Euchromatin Heterochromatin XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H3-K27 Specific) Primary MiRNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding DNA-methyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Chromatin Silencing At Telomere Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Histone Methylation Cerebellar Cortex Development Hippocampus Development B Cell Differentiation Response To Estradiol Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Trichostatin A Hepatocyte Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cell Development Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Liver Regeneration Histone H3-K27 Trimethylation Positive Regulation Of Dendrite Development Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Toxic Substance Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine Response To Drug DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation
Drugs		Tazemetostat CPI-1205	Procaine Decitabine
Diseases
GWAS		Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Macular thickness ( 30535121) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		77 interacting genes: AKT1 AR ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 H3C1 HDAC1 HOTAIR JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 USP1 VAV1 WDR61 WSB2 ZMYND11	33 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513
Entrez ID		2146	1788
HPRD ID		03342	04141
Ensembl ID		ENSG00000106462	ENSG00000119772
Uniprot IDs		A0A090N8E9 Q15910 S4S3R8	A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1
PDB IDs		2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6P5L 6U4Y	2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J
Enriched GO Terms of Interacting Partners?
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