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EPHB3 and AFDN
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro, two hybrid)
EPHB3
AFDN
Description
EPH receptor B3
afadin, adherens junction formation factor
Image
GO Annotations
Cellular Component
Extracellular Region
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Neuron Projection
Receptor Complex
Nucleoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Nuclear Speck
Cell Junction
Cell-cell Contact Zone
Pore Complex
Tight Junction
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Activity
Ephrin Receptor Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Axon Guidance Receptor Activity
Protein Binding
Protein C-terminus Binding
Small GTPase Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Biological Process
Angiogenesis
Urogenital System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Axonal Fasciculation
Cell Migration
Peptidyl-tyrosine Phosphorylation
Central Nervous System Projection Neuron Axonogenesis
Corpus Callosum Development
Regulation Of Cell-cell Adhesion
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Kinase Activity
Substrate Adhesion-dependent Cell Spreading
Regulation Of GTPase Activity
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Thymus Development
Digestive Tract Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Synapse Assembly
Roof Of Mouth Development
Dendritic Spine Development
Dendritic Spine Morphogenesis
Cell Adhesion
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Regulation Of Protein Localization
Adherens Junction Organization
Positive Regulation Of GTPase Activity
Cell-cell Adhesion Mediated By Cadherin
Pore Complex Assembly
Establishment Of Protein Localization To Plasma Membrane
Bicellular Tight Junction Assembly
Establishment Of Endothelial Intestinal Barrier
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Drugs
(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Nicotine dependence symptom count (
25555482
)
Nose size (
27182965
)
Number of alcoholic drinks required to feel an effect (long-term average) (
31270906
)
Interacting Genes
13 interacting genes:
AFDN
CRK
EFNB3
ERBB2
FBXO7
FYN
GBE1
HPCAL1
HSF2BP
LNX1
NFRKB
RASA1
RYK
37 interacting genes:
BCR
CTNNA1
EPHA7
EPHB2
EPHB3
EPHB6
F11R
HRAS
JAG1
LMO2
MRAS
NECTIN1
NECTIN2
NECTIN3
NECTIN4
NRXN1
NRXN2
NRXN3
PFN1
PICK1
RALGDS
RAP1A
RAP1GAP
RAP2A
RIN1
RIT1
RIT2
RRAS
RRAS2
SMAD2
SORBS1
SORBS2
SSX2IP
TJP1
USP9X
YWHAB
YWHAG
Entrez ID
2049
4301
HPRD ID
03502
01164
Ensembl ID
ENSG00000182580
ENSG00000130396
Uniprot IDs
P54753
A8MQ02
G1UI22
J3KN01
P55196
PDB IDs
3P1I
3ZFY
5L6O
5L6P
1T2M
1XZ9
2AIN
2EXG
5A6C
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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