EPHB1 and EFNB2

Data Source:
HPRD (in vivo, in vitro)

		EPHB1	EFNB2
Description		EPH receptor B1	ephrin B2
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Virus Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Viral Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of Chemotaxis Presynapse Assembly Positive Regulation Of Neuron Death Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC
Entrez ID		2047	1948
HPRD ID		02790	02754
Ensembl ID		ENSG00000154928	ENSG00000125266
Uniprot IDs		P54762	P52799
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW	2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL
Enriched GO Terms of Interacting Partners?
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