EPHB1 and EFNA1

Data Source:
HPRD (in vitro, in vivo)

		EPHB1	EFNA1
Description		EPH receptor B1	ephrin A1
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome	Extracellular Region Plasma Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Signaling Receptor Binding Protein Binding Ephrin Receptor Binding
	Biological Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Positive Regulation Of Protein Phosphorylation Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emotional recognition ( 31596458) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Urinary albumin excretion ( 30220432)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	14 interacting genes: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6
Entrez ID		2047	1942
HPRD ID		02790	01858
Ensembl ID		ENSG00000154928	ENSG00000169242
Uniprot IDs		P54762	P20827
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW	3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?
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