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ELAVL1 and PTGS2
Data Source:
BioGRID
(unspecified method, affinity chromatography technology, unspecified method)
ELAVL1
PTGS2
Description
ELAV like RNA binding protein 1
prostaglandin-endoperoxide synthase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Cytoplasmic Stress Granule
Membrane
Postsynapse
Glutamatergic Synapse
Ribonucleoprotein Complex
Nuclear Inner Membrane
Nuclear Outer Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Neuron Projection
Molecular Function
RNA Binding
Double-stranded RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
Protein Kinase Binding
MiRNA Binding
MRNA 3'-UTR AU-rich Region Binding
Protein Homodimerization Activity
Peroxidase Activity
Prostaglandin-endoperoxide Synthase Activity
Protein Binding
Enzyme Binding
Heme Binding
Metal Ion Binding
Dioxygenase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Protein Import Into Nucleus
Posttranscriptional Gene Silencing
Regulation Of MRNA Stability
Positive Regulation Of Translation
MRNA Stabilization
Protein Homooligomerization
Negative Regulation Of Gene Silencing By MiRNA
3'-UTR-mediated MRNA Stabilization
Regulation Of Stem Cell Population Maintenance
Prostaglandin Biosynthetic Process
Inflammatory Response
Response To Oxidative Stress
Regulation Of Blood Pressure
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cytokine-mediated Signaling Pathway
Cyclooxygenase Pathway
Lipoxygenase Pathway
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway
Long-chain Fatty Acid Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Inflammatory Response
Cellular Response To Hypoxia
Positive Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Fibroblast Growth Factor Production
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Platelet-derived Growth Factor Production
Cellular Oxidant Detoxification
Regulation Of Neuroinflammatory Response
Pathways
HuR (ELAVL1) binds and stabilizes mRNA
mRNA Splicing - Major Pathway
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs
Dihomo-gamma-linolenic acid
Icosapent
Aminosalicylic acid
Mesalazine
Acetaminophen
Indomethacin
Nabumetone
Ketorolac
Tenoxicam
Lenalidomide
Celecoxib
Tolmetin
Rofecoxib
Piroxicam
Fenoprofen
Valdecoxib
Diclofenac
Sulindac
Flurbiprofen
Etodolac
Mefenamic acid
Naproxen
Sulfasalazine
Phenylbutazone
Meloxicam
Carprofen
Diflunisal
Suprofen
Salicylic acid
Meclofenamic acid
Acetylsalicylic acid
Bromfenac
Oxaprozin
Ketoprofen
Balsalazide
Thalidomide
Ibuprofen
Lumiracoxib
Magnesium salicylate
Salsalate
Choline magnesium trisalicylate
Ginseng
Antrafenine
Antipyrine
Tiaprofenic acid
Etoricoxib
Flufenamic acid
Resveratrol
1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
Prostaglandin G2
Niflumic acid
Licofelone
Nimesulide
Cimicoxib
Lornoxicam
Aceclofenac
Nepafenac
Parecoxib
Pomalidomide
Cannabidiol
Loxoprofen
Dexibuprofen
Dexketoprofen
Droxicam
Tolfenamic acid
Firocoxib
Morniflumate
Propacetamol
Talniflumate
Phenyl salicylate
Trolamine salicylate
Menthyl salicylate
Glycol salicylate
Dipyrithione
Bryostatin 1
Alclofenac
Bufexamac
Bendazac
Acemetacin
Fish oil
Medical Cannabis
Nabiximols
Diseases
Esophageal cancer
Cholangiocarcinoma
Penile cancer
GWAS
Blood protein levels (
28240269
)
Crohn's disease (
26192919
)
Inflammatory bowel disease (
26192919
)
Knee osteoarthritis (
18471798
)
Interacting Genes
37 interacting genes:
ANP32A
ANP32B
APOE
C12orf75
CARM1
CELF2
CHEK2
CTNNB1
ERG
FAF2
GJB3
HNRNPK
HOTAIR
IL7R
KPNA1
KPNB1
MIRLET7B
MIRLET7I
NOS3
PAIP2
PLAU
PLAUR
PRKCA
PRKCD
PRKCE
PSEN2
PTBP2
PTGS2
RBFOX2
SDCBP
SET
SREK1
TNPO1
TNPO2
VCP
VEGFA
XIAP
13 interacting genes:
ABHD16A
CASK
CAV1
CELF2
COPS5
COPS7A
CTNNB1
ELAVL1
GAS5
NUCB1
PTGIS
TP53
USP22
Entrez ID
1994
5743
HPRD ID
16025
02599
Ensembl ID
ENSG00000066044
ENSG00000073756
Uniprot IDs
Q15717
P35354
PDB IDs
3HI9
4ED5
4EGL
4FXV
5SZW
6G2K
6GC5
6GD1
6GD2
6GD3
1V0X
5F19
5F1A
5IKQ
5IKR
5IKT
5IKV
5KIR
Enriched GO Terms of Interacting Partners
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