PHC1 and PCGF2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		PHC1	PCGF2
Description		polyhomeotic homolog 1	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding	DNA Binding Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Multicellular Organism Development Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899)
Interacting Genes		24 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF2 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	26 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PELI2 PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF STX2 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		1911	7703
HPRD ID		16009	10621
Ensembl ID		ENSG00000111752	ENSG00000277258
Uniprot IDs		P78364 Q6GMQ3 Q6N083	A0A024R1V6 P35227
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?
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