AGXT and TTC19

Data Source:
BioGRID (two hybrid)

		AGXT	TTC19
Description		alanine--glyoxylate and serine--pyruvate aminotransferase	tetratricopeptide repeat domain 19
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Inner Membrane Centrosome Midbody Respirasome
	Molecular Function	Serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association	Protein Binding
	Biological Process	Protein Targeting To Peroxisome Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process Response To Glucocorticoid Response To CAMP	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases		Primary hyperoxaluria (HP)	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood metabolite levels ( 24816252) Height ( 25282103 31562340) Urinary metabolites ( 26352407)
Interacting Genes		39 interacting genes: ACAT1 ATXN1L BATF3 C11orf1 C19orf54 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19	44 interacting genes: AGXT APRT ATXN1 C20orf85 CCDC33 CHMP4A COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC22A18AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688
Entrez ID		189	54902
HPRD ID		05048	07899
Ensembl ID		ENSG00000172482	ENSG00000011295
Uniprot IDs		P21549	A0A024RD83 Q6DKK2
PDB IDs		1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1
Enriched GO Terms of Interacting Partners?
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