DLG4 and PTPRG

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		DLG4	PTPRG
Description		discs large MAGUK scaffold protein 4	protein tyrosine phosphatase receptor type G
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Dendrite Cytoplasm Neuron Projection Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Kinase Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Neuroligin Family Protein Binding Scaffold Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Receptor Internalization Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cellular Response To Potassium Ion Receptor Clustering Establishment Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Protein-containing Complex Assembly Vocalization Behavior AMPA Glutamate Receptor Clustering Receptor Localization To Synapse Cell-cell Adhesion Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Neuron Projection Arborization Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior	Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Regulation Of Homophilic Cell Adhesion
Pathways		Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Guanidine Guanosine-5'-Monophosphate
Diseases
GWAS		Cholesterol, total ( 24097068 25961943) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)	Adult body size ( 32376654) Alzheimer disease and age of onset ( 26830138) Bacteremia ( 27236921) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Breast size ( 22747683) Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (sMEQ score) ( 32579418) Fuchs's corneal dystrophy ( 20825314) Ischemic stroke ( 26089329) Major depressive disorder ( 20125088 29317602) Metabolite levels ( 23823483) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) QT interval ( 20031603) Smoking initiation (ever regular vs never regular) ( 30679032) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Stroke ( 26089329)
Interacting Genes		109 interacting genes: ACTN2 ADGRB1 ADGRL1 ADRB1 AKAP5 ARHGAP32 ARRB2 ASIC3 ATP2B2 ATP2B4 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRHR1 CRIPT CYLD DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB4 ERBIN EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG RPS6KA1 SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TAMALIN TANC1 TRAF6 WNT3A YES1 ZDHHC17	3 interacting genes: DLG4 PKD1 PKD2
Entrez ID		1742	5793
HPRD ID		04199	01478
Ensembl ID		ENSG00000132535	ENSG00000144724
Uniprot IDs		B7Z4H2 B7Z647 B9EGL1 P78352	P23470 Q49A02
PDB IDs		1KEF 2MES 3I4W 3K82 3ZRT 5J7J 5JXB 6QJD 6QJF 6QJG 6QJI 6QJJ 6QJK 6QJL 6QJN 6SPV 6SPZ	2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN 5E5R
Enriched GO Terms of Interacting Partners?
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