PTPRG and PKD1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PTPRG	PKD1
Description		protein tyrosine phosphatase receptor type G	polycystin 1, transient receptor potential channel interacting
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GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Extracellular Exosome	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Ion Channel Binding
	Biological Process	Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Regulation Of Homophilic Cell Adhesion	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Adult body size ( 32376654) Alzheimer disease and age of onset ( 26830138) Bacteremia ( 27236921) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Breast size ( 22747683) Daytime sleep phenotypes ( 27126917) Evening vs. morning chronotype (sMEQ score) ( 32579418) Fuchs's corneal dystrophy ( 20825314) Ischemic stroke ( 26089329) Major depressive disorder ( 20125088 29317602) Metabolite levels ( 23823483) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) QT interval ( 20031603) Smoking initiation (ever regular vs never regular) ( 30679032) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Stroke ( 26089329)	Appendicular lean mass ( 33097823) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		3 interacting genes: DLG4 PKD1 PKD2	30 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		5793	5310
HPRD ID		01478	03203
Ensembl ID		ENSG00000144724	ENSG00000008710
Uniprot IDs		P23470 Q49A02	P98161
PDB IDs		2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN 5E5R	1B4R 6A70
Enriched GO Terms of Interacting Partners?
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