DLD and PDHX

Data Source:
HPRD (in vitro)

		DLD	PDHX
Description		dihydrolipoamide dehydrogenase	pyruvate dehydrogenase complex component X
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Motile Cilium Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyl Dehydrogenase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Lipoamide Binding Flavin Adenine Dinucleotide Binding NAD Binding	Protein Binding Transferase Activity, Transferring Acyl Groups Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Pyruvate Metabolic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Aging Branched-chain Amino Acid Catabolic Process Lipoate Metabolic Process Regulation Of Membrane Potential Cell Redox Homeostasis Sperm Capacitation Dihydrolipoamide Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate Histone Succinylation	Pyruvate Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle)	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		NADH Flavin adenine dinucleotide
Diseases		Maple syrup urine disease (MSUD) Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233 20228799 19122664) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)
Interacting Genes		4 interacting genes: ITGB1BP1 OGDH PDHX SLC2A4	10 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 PDHB PDK2
Entrez ID		1738	8050
HPRD ID		02006	02002
Ensembl ID		ENSG00000091140	ENSG00000110435
Uniprot IDs		A0A024R713 E9PEX6 P09622	O00330
PDB IDs		1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z	1ZY8 2DNC 2F5Z 2F60 6H60
Enriched GO Terms of Interacting Partners?
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