DLD and OGDH

Data Source:
HPRD (in vitro)

		DLD	OGDH
Description		dihydrolipoamide dehydrogenase	oxoglutarate dehydrogenase
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Motile Cilium Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyl Dehydrogenase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Lipoamide Binding Flavin Adenine Dinucleotide Binding NAD Binding	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Thiamine Pyrophosphate Binding Metal Ion Binding
	Biological Process	Pyruvate Metabolic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Aging Branched-chain Amino Acid Catabolic Process Lipoate Metabolic Process Regulation Of Membrane Potential Cell Redox Homeostasis Sperm Capacitation Dihydrolipoamide Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate Histone Succinylation	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Histone Succinylation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle)	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs		NADH Flavin adenine dinucleotide	NADH Valproic acid Xanthinol
Diseases		Maple syrup urine disease (MSUD) Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233 20228799 19122664) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Low density lipoprotein cholesterol levels ( 32154731) Lung cancer in never smokers ( 28604730) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		4 interacting genes: ITGB1BP1 OGDH PDHX SLC2A4	5 interacting genes: ANXA2 DLD DLST HSD17B10 PLSCR1
Entrez ID		1738	4967
HPRD ID		02006	08938
Ensembl ID		ENSG00000091140	ENSG00000105953
Uniprot IDs		A0A024R713 E9PEX6 P09622	A0A140VJQ5 B4E3E9 E9PCR7 Q02218
PDB IDs		1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z	3ERY
Enriched GO Terms of Interacting Partners?
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