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DFFA and CASP7
Data Source:
HPRD
(in vitro)
DFFA
CASP7
Description
DNA fragmentation factor subunit alpha
caspase 7
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein-containing Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein Domain Specific Binding
Protein Folding Chaperone
Deoxyribonuclease Inhibitor Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Apoptotic DNA Fragmentation
Negative Regulation Of Deoxyribonuclease Activity
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Chaperone-mediated Protein Folding
Thymocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Apoptotic DNA Fragmentation
Proteolysis
Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Pathways
Apoptosis induced DNA fragmentation
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Fica
Emricasan
Incadronic acid
Diseases
GWAS
Depression in smokers (
30219690
)
Male-pattern baldness (
29146897
28196072
)
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
27723757
22561518
)
Interacting Genes
11 interacting genes:
CASP3
CASP7
CIDEB
DFFB
EWSR1
GZMB
GZMM
NECAB2
STRN4
YWHAG
YWHAZ
62 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
UBE4B
VIM
XIAP
Entrez ID
1676
840
HPRD ID
03531
03457
Ensembl ID
ENSG00000160049
ENSG00000165806
Uniprot IDs
A0A024R4H5
O00273
A0A0A0MRL7
B4DWA2
P55210
PDB IDs
1IBX
1IYR
1KOY
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1MIA
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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