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CASP7 and BIRC2
Data Source:
HPRD
(in vitro)
CASP7
BIRC2
Description
caspase 7
baculoviral IAP repeat containing 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
XY Body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Ubiquitin Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
FBXO Family Protein Binding
Biological Process
Proteolysis
Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Protein Polyubiquitination
Response To Hypoxia
Placenta Development
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of RIG-I Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Response To Ethanol
Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Inflammatory Response
Response To CAMP
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Necroptotic Process
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Protein K48-linked Ubiquitination
Positive Regulation Of Protein Monoubiquitination
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Fica
Emricasan
Incadronic acid
Diseases
GWAS
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
27723757
22561518
)
Prostate cancer (
23535732
)
Interacting Genes
62 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
UBE4B
VIM
XIAP
75 interacting genes:
ABHD17A
BIRC5
BLK
BMX
BOLA1
BOLA2
BOLA2B
CASP3
CASP7
CASP9
CBLC
CD40
CDC42
CSE1L
DIABLO
DZIP3
E2F1
EAF2
EIF4E
EXOSC5
FBXO7
GAS1
GCC1
GFAP
GLMN
GSPT1
HSP90B1
HTRA2
IGF2BP1
IKBKE
IKBKG
JUP
KDM1A
LNX1
LTBR
MAD1L1
MAGEA11
MAP3K2
MAP3K3
NMB
NXF1
OTUB1
PACS2
PCSK9
PFN2
PPM1K
RAC1
RAF1
RFC5
RHOA
RIPK2
RIPK3
RIPK4
RNF181
RUNX1T1
TCAF1
TRADD
TRAF1
TRAF2
TRIM34
TSG101
TSGA10
TUFT1
UBB
UBC
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2J1
UBE2N
UBE2Q2
UBE2S
UBE2V1
UBE2W
Entrez ID
840
329
HPRD ID
03457
03419
Ensembl ID
ENSG00000165806
ENSG00000110330
Uniprot IDs
A0A0A0MRL7
B4DWA2
P55210
Q13490
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1MIA
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
1QBH
2L9M
3D9T
3D9U
3M1D
3MUP
3OZ1
3T6P
3UW4
4EB9
4HY4
4HY5
4KMN
4LGE
4LGU
4MTI
4MU7
5M6N
6EXW
6HPR
Enriched GO Terms of Interacting Partners
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