DAPK3 and TCP10L

Data Source:
BioGRID (two hybrid)

		DAPK3	TCP10L
Description		death associated protein kinase 3	t-complex 10 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Actin Filament PML Body Membrane Raft	Nucleus Centriole
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding CAMP Response Element Binding Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transcription Corepressor Activity Protein Binding Identical Protein Binding Protein Self-association Repressing Transcription Factor Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib
Diseases
GWAS		Age-related macular degeneration ( 23326517) Expressive vocabulary in infants ( 25226531)
Interacting Genes		15 interacting genes: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53	34 interacting genes: APP C2CD6 CCDC102B CCDC57 CCDC70 CDR2L CIAO1 DAPK3 FBXO25 FHL2 FRS3 GRIPAP1 IKBKG LMO1 LMO2 LMO3 LRRK2 MAPK9 MFAP1 MXD4 NCK2 NTAQ1 NXF1 PMF1 PRPH RALBP1 SAAL1 SMARCD1 TCEANC TNNC1 TNS2 TRIM55 TRIM63 TSSK3
Entrez ID		1613	140290
HPRD ID		04478	10518
Ensembl ID		ENSG00000167657	ENSG00000242220
Uniprot IDs		B3KNJ3 O43293	Q8TDR4
PDB IDs		1YRP 2J90 3BHY 3BQR 5A6N 5A6O 5VJA
Enriched GO Terms of Interacting Partners?
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