TCP10L and FBXO25

Data Source:
BioGRID (enzymatic study)

		TCP10L	FBXO25
Description		t-complex 10 like	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Centriole	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding Protein Self-association Repressing Transcription Factor Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS			Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		34 interacting genes: APP C2CD6 CCDC102B CCDC57 CCDC70 CDR2L CIAO1 DAPK3 FBXO25 FHL2 FRS3 GRIPAP1 IKBKG LMO1 LMO2 LMO3 LRRK2 MAPK9 MFAP1 MXD4 NCK2 NTAQ1 NXF1 PMF1 PRPH RALBP1 SAAL1 SMARCD1 TCEANC TNNC1 TNS2 TRIM55 TRIM63 TSSK3	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		140290	26260
HPRD ID		10518	16439
Ensembl ID		ENSG00000242220	ENSG00000147364
Uniprot IDs		Q8TDR4	A0A024QZ88 Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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