SPC24 and SKA2

Data Source:
BioGRID (two hybrid)

		SPC24	SKA2
Description		SPC24 component of NDC80 kinetochore complex	spindle and kinetochore associated complex subunit 2
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Cell Cycle Cell Division	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)	Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN	6 interacting genes: HMOX2 IFT57 PRKD3 RALY SKA1 SPC24
Entrez ID		147841	348235
HPRD ID		15464	13306
Ensembl ID		ENSG00000161888	ENSG00000182628
Uniprot IDs		B4E086 Q8NBT2	J3KSP0 Q8WVK7
PDB IDs		2VE7 3IZ0	4AJ5
Enriched GO Terms of Interacting Partners?
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