SPC24

Description		SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding
	Biological Process	Cell Cycle Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN
Entrez ID		147841
HPRD ID		15464
Ensembl ID		ENSG00000161888
Uniprot IDs		B4E086 Q8NBT2
PDB IDs		2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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