CSNK1G2 and IRS4

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		CSNK1G2	IRS4
Description		casein kinase 1 gamma 2	insulin receptor substrate 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway	Signal Transduction Insulin Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane	IRS-related events triggered by IGF1R
Drugs		IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Body mass index ( 25673413) Coronary artery disease ( 29212778) Red cell distribution width ( 32888494 27863252)
Interacting Genes		14 interacting genes: APP APPBP2 CERT1 DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 WDCP	22 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		1455	8471
HPRD ID		03738	04620
Ensembl ID		ENSG00000133275	ENSG00000133124
Uniprot IDs		P78368	O14654
PDB IDs		2C47
Enriched GO Terms of Interacting Partners?
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