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CRX and PSMB10
Data Source:
BioGRID
(two hybrid)
CRX
PSMB10
Description
cone-rod homeobox
proteasome 20S subunit beta 10
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
RNA Polymerase II Transcription Regulator Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Spermatoproteasome Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Hormone Receptor Binding
Leucine Zipper Domain Binding
Sequence-specific Double-stranded DNA Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Visual Perception
Animal Organ Morphogenesis
Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Response To Stimulus
MAPK Cascade
Protein Polyubiquitination
Cell Morphogenesis
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Humoral Immune Response
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
T Cell Proliferation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Carfilzomib
Diseases
Leber congenital amaurosis (LCR)
Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Crohn's disease (
22412388
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
112 interacting genes:
AASDHPPT
ABI2
ACBD4
ARIH2
ATG12
ATM
ATP6V0D2
ATXN1
ATXN7
BANF1
BANF2
BANP
BOD1L2
C19orf25
C1orf109
C1orf50
C1orf56
C9orf72
CA8
CCNC
CDKN2C
CFAP206
CREBBP
CSNK1G2-AS1
CTNNA3
DELE1
EIF5A
EP300
FAAP20
FOXH1
GCM2
GLIS2
GUCD1
GYS1
HGS
HNF1B
IGFN1
IPO13
IRX6
KANK2
KAT2A
KLHL32
LARP4
LGALS3
LIMS3
LIMS4
LNX1
LONRF1
M1AP
MDFI
MLLT6
MYO15B
MYOZ1
NEIL2
NFYC
NIP7
NPAS2
NR2E3
NRL
NTF4
OR6B1
OSGIN1
OSTF1
PDC
PICALM
PID1
PNMA6A
POGZ
PPP1R16B
PRKAB2
PRKN
PRR35
PSMA1
PSMB10
PSMF1
QRICH1
RAX2
RBFOX1
RBPMS
RHOXF2
ROR2
SAE1
SDCBP
SEC14L4
SFI1
SMAD3
SMAP1
SMAP2
SMUG1
SOX10
SOX14
SOX3
SOX5
SPG21
STK16
SUFU
SUOX
SZT2
TBX6
TCF7L2
TEX33
TFG
TLE5
TLX3
TNS2
UBXN2B
UBXN7
VPS37C
ZC3H10
ZIC1
ZNF483
ZNF688
11 interacting genes:
ANXA7
CCNDBP1
CRX
MEOX2
POMP
PSMA1
PSMA2
PSMA3
PSMB8
PSMB9
PTN
Entrez ID
1406
5699
HPRD ID
03748
01465
Ensembl ID
ENSG00000105392
ENSG00000205220
Uniprot IDs
O43186
P40306
PDB IDs
6AVO
6E5B
6HV3
6HV4
6HV5
6HV7
6HVA
6HVR
6HVS
6HVT
6HVU
6HVV
6HVW
Enriched GO Terms of Interacting Partners
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