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ROCK1 and UBE2T
Data Source:
BioGRID
(enzymatic study)
ROCK1
UBE2T
Description
Rho associated coiled-coil containing protein kinase 1
ubiquitin conjugating enzyme E2 T
Image
GO Annotations
Cellular Component
Golgi Membrane
Ruffle
Extracellular Region
Cytoplasm
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Stress Granule
Lamellipodium
Bleb
Secretory Granule Lumen
Amyloid-beta Complex
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Aspartic-type Endopeptidase Inhibitor Activity
Metal Ion Binding
Tau Protein Binding
Tau-protein Kinase Activity
Rho-dependent Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Mitotic Cytokinesis
Aortic Valve Morphogenesis
Protein Phosphorylation
Apoptotic Process
Smooth Muscle Contraction
Leukocyte Cell-cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Rho Protein Signal Transduction
Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Angiogenesis
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Membrane To Membrane Docking
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Regulation Of Cell Migration
Cortical Actin Cytoskeleton Organization
Actomyosin Structure Organization
Neuron Projection Development
Negative Regulation Of Protein Binding
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Myosin-light-chain-phosphatase Activity
Negative Regulation Of Phosphorylation
Neutrophil Degranulation
Positive Regulation Of MAPK Cascade
Regulation Of Keratinocyte Differentiation
Regulation Of Neuron Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Embryonic Morphogenesis
Leukocyte Migration
Leukocyte Tethering Or Rolling
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Myoblast Migration
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Focal Adhesion Assembly
MRNA Destabilization
Negative Regulation Of Biomineral Tissue Development
Regulation Of Microtubule Cytoskeleton Organization
Response To Transforming Growth Factor Beta
Protein Localization To Plasma Membrane
Glomerular Visceral Epithelial Cell Migration
Blood Vessel Diameter Maintenance
Regulation Of Angiotensin-activated Signaling Pathway
Neuron Projection Arborization
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cell Junction Assembly
Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Connective Tissue Replacement
Response To Angiotensin
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Protein Polyubiquitination
DNA Repair
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein K29-linked Ubiquitination
Interstrand Cross-link Repair
Protein K27-linked Ubiquitination
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Pathways
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
Neutrophil degranulation
RHOBTB1 GTPase cycle
Potential therapeutics for SARS
Fanconi Anemia Pathway
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Hydroxyfasudil
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
Fasudil
Y-27632
Ripasudil
Netarsudil
Diseases
GWAS
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Lysophosphatidylcholine levels (
31551469
)
Telomere length (
30185882
)
Breast cancer (
23535733
)
Celiac disease (
23936387
)
Interacting Genes
36 interacting genes:
ADD1
ARHGAP24
CASP3
CASP7
CDC25A
CDC34
CFAP206
CRMP1
DES
DPYSL2
EZR
FAM124A
GFAP
IKBKB
IRS1
ITSN2
LIMK1
LIMK2
LMO2
MAGEB4
MLC1
MSN
PFN2
POLR3C
PPP1R12A
PTK2
RDX
RHOA
RHOC
RND3
SMAD2
TPPP
TRIM15
TSG101
UBE2T
VIM
22 interacting genes:
AMFR
ARIH2
BRCA1
CDK2
CHEK1
FANCD2
FANCL
LNX2
MARCHF5
MGRN1
PCGF2
PRKCG
PRKN
RNF128
RNF144B
RNF31
RNF4
ROCK1
RPS6KA1
TRIM27
UBA1
UBA6
Entrez ID
6093
29089
HPRD ID
03414
13704
Ensembl ID
ENSG00000067900
ENSG00000077152
Uniprot IDs
Q13464
A0A024R9A9
Q9NPD8
PDB IDs
1S1C
2ESM
2ETK
2ETR
2V55
3D9V
3NCZ
3NDM
3O0Z
3TV7
3TWJ
3V8S
4L2W
4W7P
4YVC
4YVE
5BML
5F5P
5HVU
5KKS
5KKT
5UZJ
5WNE
5WNF
5WNG
5WNH
6E9W
7JOU
1YH2
4CCG
5NGZ
5OJJ
6R75
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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