CPS1 and ARAF

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CPS1	ARAF
Description		carbamoyl-phosphate synthase 1	A-Raf proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrial Inner Membrane Mitochondrial Matrix Protein-containing Complex Mitochondrial Nucleoid	Cellular_component Mitochondrion Cytosol
	Molecular Function	Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Endopeptidase Activity Calcium Ion Binding Protein Binding ATP Binding Phospholipid Binding Glutamate Binding Protein-containing Complex Binding Modified Amino Acid Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Urea Cycle 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Proteolysis Glutamine Metabolic Process Nitrogen Compound Metabolic Process Midgut Development Response To Toxic Substance Response To Zinc Ion Response To Amine Citrulline Biosynthetic Process Triglyceride Catabolic Process Response To Food Response To Lipopolysaccharide Vasodilation Response To Drug Response To Starvation Response To Amino Acid Cellular Response To Fibroblast Growth Factor Stimulus Nitric Oxide Metabolic Process Homocysteine Metabolic Process Anion Homeostasis Response To Growth Hormone Hepatocyte Differentiation Carbamoyl Phosphate Biosynthetic Process Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Response To Dexamethasone	MAPK Cascade Activation Of MAPKK Activity Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways		Urea cycle	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants
Drugs		Carglumic acid	ATP
Diseases		Carbamoyl phosphate synthetase I deficiency	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Acylcarnitine levels ( 26068415) Alanine transaminase levels ( 29403010) Alzheimer's disease in APOE e4+ carriers ( 25778476) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 25673413) Body mass index in asthmatics ( 23517042) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462 29403010) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Homocysteine levels ( 23824729 20154341) Lymphocyte counts ( 32888494) Macular telangiectasia type 2 ( 28250457) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494 27863252) Metabolic traits ( 21886157) Metabolite levels ( 31628463 23378610) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte count ( 32888494) Neutrophil count ( 32888494) Non-small cell lung cancer ( 23144319) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Positive urgency ( 30718321) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 31636271 24625756 25569235) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Urate levels in obese individuals ( 25811787) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407) Urinary potassium to creatinine ratio ( 30910378) Urinary sodium to creatinine ratio ( 30910378) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: ARAF HSD17B10 RAF1	59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG
Entrez ID		1373	369
HPRD ID		01995	02405
Ensembl ID		ENSG00000021826	ENSG00000078061
Uniprot IDs		A0A024R454 P31327 Q6PEK7	A0A024R178 P10398 Q96II5
PDB IDs		2YVQ 4UTR 4UTV 4UTX 4UTZ 4UU7 4UU8 4UUA 4UUB 5DOT 5DOU 5OJO 6UEL	1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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