ARAF and DIDO1

Data Source:
BioGRID (two hybrid)

		ARAF	DIDO1
Description		A-Raf proto-oncogene, serine/threonine kinase	death inducer-obliterator 1
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GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Nucleus Cytoplasm Spindle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process	Transcription, DNA-templated Apoptotic Signaling Pathway
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants
Drugs		ATP
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 26414677)
Interacting Genes		59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	12 interacting genes: APP ARAF DVL3 H3-4 HNRNPK KCNK4 LRRK2 SRPK2 SRSF1 SUMO2 WWP1 WWP2
Entrez ID		369	11083
HPRD ID		02405	10363
Ensembl ID		ENSG00000078061	ENSG00000101191
Uniprot IDs		A0A024R178 P10398 Q96II5	Q9BTC0
PDB IDs		1WXM 2MSE	2M3H 4L7X
Enriched GO Terms of Interacting Partners?
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