KLHL40 and MCM10

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KLHL40	MCM10
Description		kelch like family member 40	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	Protein Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS			Nicotine dependence symptom count ( 25555482)
Interacting Genes		13 interacting genes: AHNAK C7orf31 CC2D1B FSD2 LMOD3 LRRC29 MCM10 REL SAXO1 TASOR2 VDAC1 ZBED1 ZNF451	38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		131377	55388
HPRD ID		11058	11297
Ensembl ID		ENSG00000157119	ENSG00000065328
Uniprot IDs		A8K5H9 Q2TBA0	Q7L590
PDB IDs		4ASC
Enriched GO Terms of Interacting Partners?
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