MCM10 and RECQL4

Data Source:
BioGRID (pull down)

		MCM10	RECQL4
Description		minichromosome maintenance 10 replication initiation factor	RecQ like helicase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane
	Molecular Function	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Oxidized Purine DNA Binding Annealing Helicase Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases			RAPADILINO syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Nicotine dependence symptom count ( 25555482)	Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	7 interacting genes: ACD EP300 MCM10 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		55388	9401
HPRD ID		11297	04805
Ensembl ID		ENSG00000065328	ENSG00000160957
Uniprot IDs		Q7L590	O94761
PDB IDs			2KMU 5LST
Enriched GO Terms of Interacting Partners?
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