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H3C14 and VRK1
Data Source:
BioGRID
(pull down, enzymatic study)
H3C14
VRK1
Description
H3 clustered histone 14
VRK serine/threonine kinase 1
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Stack
Spindle
Cytosol
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Nucleosomal Histone Binding
Histone Kinase Activity (H3-S10 Specific)
Histone Kinase Activity (H3-T3 Specific)
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
RDNA Heterochromatin Assembly
Chromatin Organization
Nucleosome Assembly
Blood Coagulation
Interleukin-7-mediated Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Protein Phosphorylation
Mitotic Nuclear Envelope Disassembly
Mitotic Nuclear Envelope Reassembly
Peptidyl-serine Phosphorylation
Histone H3-S10 Phosphorylation
Protein Autophosphorylation
Cell Division
Histone H3-T3 Phosphorylation
Golgi Disassembly
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
Nuclear Envelope Breakdown
Initiation of Nuclear Envelope (NE) Reformation
Drugs
Diseases
Pontocerebellar hypoplasia
GWAS
Bone ultrasound measurement (velocity of sound) (
28472463
)
Carboplatin disposition in epthelial ovarian cancer (
29367611
)
Cognitive function (
24684796
)
Copper levels (
26025379
)
Fractures (paediatric) (
32742401
)
Metabolite levels (
23823483
)
Neutrophil count (
21507922
)
Night sleep phenotypes (
27126917
)
Staphylococcus aureus infection (
24847357
)
Interacting Genes
60 interacting genes:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFL2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
NAP1L4
NASP
NCOA6
NRDC
NSD2
PHF21A
PIM1
PKN1
PRMT6
PTMA
PWWP3A
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
6 interacting genes:
H2BC21
H3C14
NBN
PLK3
SRPK2
TP53
Entrez ID
126961
7443
HPRD ID
11822
03701
Ensembl ID
ENSG00000203811
ENSG00000100749
Uniprot IDs
Q71DI3
Q99986
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
6ACE
6FML
6T79
6T7A
6T7B
6T7C
6T7D
6X59
6X5A
6XJD
6Y5D
6Y5E
7BQZ
7BU9
7JO9
7JOA
2KTY
2KUL
2LAV
2RSV
3OP5
5UKF
5UVF
6AC9
6BP0
6BRU
6BTW
6BU6
6CFM
6CMM
6CNX
6CQH
6CSW
6DD4
6NPN
6VZH
Enriched GO Terms of Interacting Partners
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