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H3C14 and UHRF1
Data Source:
BioGRID
(affinity chromatography technology, x-ray crystallography, x-ray crystallography, unspecified method, unspecified method)
H3C14
UHRF1
Description
H3 clustered histone 14
ubiquitin like with PHD and ring finger domains 1
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Exosome
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Replication Fork
Nuclear Matrix
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Cis-regulatory Region Sequence-specific DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Methyl-CpG Binding
Nucleosomal Histone Binding
Methylated Histone Binding
Histone Binding
Identical Protein Binding
Hemi-methylated DNA-binding
Ubiquitin Protein Ligase Activity
Biological Process
RDNA Heterochromatin Assembly
Chromatin Organization
Nucleosome Assembly
Blood Coagulation
Interleukin-7-mediated Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Maintenance Of DNA Methylation
Histone Monoubiquitination
Protein Ubiquitination
Histone Ubiquitination
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Epithelial Cell Proliferation
Protein Autoubiquitination
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
DNA methylation
Drugs
Diseases
GWAS
Birth weight (
31043758
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Mental health study participation (completed survey) (
31263887
)
Systolic blood pressure (
30578418
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
60 interacting genes:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFL2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
NAP1L4
NASP
NCOA6
NRDC
NSD2
PHF21A
PIM1
PKN1
PRMT6
PTMA
PWWP3A
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
26 interacting genes:
DNMT1
DNMT3A
ERCC1
ERG
FANCD2
H2AC4
H2BC3
H3-4
H3C1
H3C13
H3C14
H3C15
H4C14
KAT5
LASP1
LIG1
MBD4
MUS81
PCLAF
PCNA
PRKACA
TP53
UBE2D1
UBE2D3
UBE2N
UHRF2
Entrez ID
126961
29128
HPRD ID
11822
06992
Ensembl ID
ENSG00000203811
ENSG00000276043
Uniprot IDs
Q71DI3
A0A087WVR3
Q96T88
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
6ACE
6FML
6T79
6T7A
6T7B
6T7C
6T7D
6X59
6X5A
6XJD
6Y5D
6Y5E
7BQZ
7BU9
7JO9
7JOA
2FAZ
2L3R
2LGG
2LGK
2LGL
2PB7
3ASK
3ASL
3BI7
3CLZ
3DB3
3DB4
3DWH
3FL2
3SHB
3SOU
3SOW
3SOX
3T6R
3ZVY
3ZVZ
4GY5
4QQD
5C6D
5IAY
5XPI
5YY9
5YYA
6B9M
6IIW
6VCS
6VED
Enriched GO Terms of Interacting Partners
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