MBD3L2 and CHD4

Data Source:
BioGRID (pull down)

		MBD3L2	CHD4
Description		methyl-CpG binding domain protein 3 like 2	chromodomain helicase DNA binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)
Interacting Genes		20 interacting genes: CCDC136 CHD4 GOLGA6L9 GPRASP2 HDAC1 HDAC2 KRT27 KRT34 KRTAP6-3 MBD2 MBD3 MDFI MTA1 MTA2 POLD3 RBBP4 RBBP7 RUNDC3A SBK3 TRIML2	21 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1
Entrez ID		125997	1108
HPRD ID		12139	04472
Ensembl ID		ENSG00000230522	ENSG00000111642
Uniprot IDs		Q8NHZ7	F5GWX5 Q14839
PDB IDs			1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU
Enriched GO Terms of Interacting Partners?
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