CCR1 and DUSP7

Data Source:
BioGRID (affinity chromatography technology)

		CCR1	DUSP7
Description		C-C motif chemokine receptor 1	dual specificity phosphatase 7
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of MAP Kinase Activity
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	7 interacting genes: EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8
Entrez ID		1230	1849
HPRD ID		03101	04125
Ensembl ID		ENSG00000163823	ENSG00000164086
Uniprot IDs		P32246 Q5U003	Q16829
PDB IDs		1Y5D	4Y2E
Enriched GO Terms of Interacting Partners?
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