CCR1 and CCL26

Data Source:
HPRD (in vivo)

		CCR1	CCL26
Description		C-C motif chemokine receptor 1	C-C motif chemokine ligand 26
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Space
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Carotid plaque burden ( 28282560) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	24 interacting genes: APP C3orf52 CCL11 CCL13 CCL17 CCL2 CCL21 CCL28 CCL5 CCL8 CCR1 CCR3 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 PAX6 PF4 PF4V1 PPBP XCL1 XCL2
Entrez ID		1230	10344
HPRD ID		03101	05262
Ensembl ID		ENSG00000163823	ENSG00000006606
Uniprot IDs		P32246 Q5U003	Q9Y258
PDB IDs		1Y5D	1G2S 1G2T
Enriched GO Terms of Interacting Partners?
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