FMNL2 and PRPF40A

Data Source:
HPRD (two hybrid)

		FMNL2	PRPF40A
Description		formin like 2	pre-mRNA processing factor 40 homolog A
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Cadherin Binding Actin Filament Binding	RNA Binding Protein Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Cortical Actin Cytoskeleton Organization	MRNA Splicing, Via Spliceosome Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways		RHO GTPases Activate Formins	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 27611488) Corneal astigmatism ( 30306274) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Refractive astigmatism ( 30306274) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) White blood cell count ( 32888494)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: AP1B1 AP2B1 APP CCDC197 CDC42 KRT27 MIPOL1 NECAB1 PNMA1 PRPF40A SUOX TXN2	130 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 C4orf45 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		114793	55660
HPRD ID		13545	10995
Ensembl ID		ENSG00000157827	ENSG00000196504
Uniprot IDs		Q96PY5	O75400
PDB IDs		4YC7	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS
Enriched GO Terms of Interacting Partners?
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