PRPF40A and SF3A3

Data Source:
BioGRID (pull down)

		PRPF40A	SF3A3
Description		pre-mRNA processing factor 40 homolog A	splicing factor 3a subunit 3
Image
GO Annotations	Cellular Component	Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	RNA Splicing, Via Transesterification Reactions MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing U2-type Prespliceosome Assembly
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418)
Interacting Genes		130 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 C4orf45 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	38 interacting genes: ADAP1 APBB1 APP CCDC85B HSPB1 MIR106B MIR107 MIR141 MIR145 MIR155 MIR199A1 MIR200A MIR200C MIR206 MIR214 MIR221 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MTNR1B PRMT5 PRPF40A SF3A1 SREK1 TADA2A TCERG1 TRIM69 U2AF1 VAV2 WBP4 ZDHHC17 ZNF212
Entrez ID		55660	10946
HPRD ID		10995	10411
Ensembl ID		ENSG00000196504	ENSG00000183431
Uniprot IDs		O75400	B4DW90 Q12874
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS	2DT7 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6QX9 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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