TOE1 and UNC13B

Data Source:
HPRD (two hybrid)

		TOE1	UNC13B
Description		target of EGR1, exonuclease	unc-13 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck	Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding SnRNA Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	SnRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Chemical Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Maturation Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis Presynaptic Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS			Parkinson's disease ( 21812969)
Interacting Genes		25 interacting genes: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83	11 interacting genes: CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		114034	10497
HPRD ID		18212	05785
Ensembl ID		ENSG00000132773	ENSG00000198722
Uniprot IDs		Q96GM8	O14795 Q4LE73
PDB IDs		2FC6
Enriched GO Terms of Interacting Partners?
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