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CHRM5 and ERCC1
Data Source:
BioGRID
(two hybrid)
CHRM5
ERCC1
Description
cholinergic receptor muscarinic 5
ERCC excision repair 1, endonuclease non-catalytic subunit
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
Postsynaptic Membrane
Nucleotide-excision Repair Complex
Nucleotide-excision Repair Factor 1 Complex
Chromosome, Telomeric Region
Nucleoplasm
Cytoplasm
ERCC4-ERCC1 Complex
Molecular Function
Phosphatidylinositol Phospholipase C Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
G Protein-coupled Acetylcholine Receptor Activity
Neurotransmitter Receptor Activity
Single-stranded DNA Endodeoxyribonuclease Activity
TFIID-class Transcription Factor Complex Binding
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
Promoter-specific Chromatin Binding
Biological Process
Gastric Acid Secretion
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Chemical Synaptic Transmission
Dopamine Transport
Transmission Of Nerve Impulse
Regulation Of Phosphatidylinositol Dephosphorylation
G Protein-coupled Serotonin Receptor Signaling Pathway
Meiotic Mismatch Repair
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Mitotic Recombination
Syncytium Formation
Response To Oxidative Stress
Spermatogenesis
Response To Nutrient
Cell Population Proliferation
Male Gonad Development
UV Protection
Response To Sucrose
Response To X-ray
Multicellular Organism Aging
Negative Regulation Of Telomere Maintenance
Nucleotide-excision Repair, DNA Incision
Post-embryonic Hemopoiesis
Multicellular Organism Growth
Response To Immobilization Stress
Interstrand Cross-link Repair
Isotype Switching
Response To Cadmium Ion
Oogenesis
Embryonic Organ Development
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Telomeric DNA-containing Double Minutes Formation
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Replicative Senescence
T-circle Formation
Positive Regulation Of T-circle Formation
Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways
Muscarinic acetylcholine receptors
G alpha (q) signalling events
HDR through Single Strand Annealing (SSA)
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Fanconi Anemia Pathway
Drugs
Ziprasidone
Amitriptyline
Metixene
Terfenadine
Clozapine
Doxylamine
Trihexyphenidyl
Loxapine
Meperidine
Imipramine
Darifenacin
Nortriptyline
Amoxapine
Cinnarizine
Atropine
Nicardipine
Paroxetine
Homatropine methylbromide
Trimipramine
Scopolamine
Benzquinamide
Propiomazine
Brompheniramine
Maprotiline
Methantheline
Tolterodine
Promethazine
Doxepin
Desipramine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Methotrimeprazine
Tiotropium
Solifenacin
ALKS 27
Fesoterodine
Aclidinium
Umeclidinium
Dosulepin
Etoperidone
Homatropine
Thonzylamine
Revefenacin
Propiverine
Rociverine
Aripiprazole lauroxil
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Malaria (
31844061
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x age interaction (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Simvastatin-induced myopathy (
31220337
)
Interacting Genes
31 interacting genes:
ASPH
ASTN2
ATP2A2
ATP9A
CBFB
CD82
EPB41L1
EPC1
ERCC1
GJB6
GOLGA8A
GPRASP1
HLA-F
MAP3K1
MSMO1
MYH7
NLE1
NPAS3
PRSS16
REEP5
RGS7
RTN1
SLC2A6
SLC5A6
SLC6A8
SMAD6
SNCA
SPNS1
STARD3NL
TMEM161A
USP33
18 interacting genes:
APP
CHRM5
ERCC4
GAS8
KIF11
MKRN3
RAD52
RPA1
RPA2
RPA3
SLX1A
TRMT2B
UBL7
UHRF1
USHBP1
USP45
VPS37B
XPA
Entrez ID
1133
2067
HPRD ID
00331
00533
Ensembl ID
ENSG00000184984
ENSG00000012061
Uniprot IDs
A0A024R9I2
P08912
Q8IVW0
A0A024R0Q6
P07992
PDB IDs
6OL9
1Z00
2A1I
2A1J
2JNW
2JPD
2MUT
6SXA
6SXB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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