RAPGEF4 and MAP1A

Data Source:
HPRD (in vivo)

		RAPGEF4	MAP1A
Description		Rap guanine nucleotide exchange factor 4	microtubule associated protein 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Axon Dendrite Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Dendritic Branch Synapse Primary Dendrite Dendritic Microtubule Axon Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding	Actin Binding Structural Molecule Activity Protein Binding Microtubule Binding Cytoskeletal Anchor Activity Tubulin Binding Tau Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle	Microtubule Cytoskeleton Organization Axonogenesis Memory Associative Learning Dendrite Development Regulation Of Microtubule Depolymerization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Synaptic Plasticity Voluntary Musculoskeletal Movement Neuron Cellular Homeostasis Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Cellular Protein Localization Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs			Estramustine
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)	Hemoglobin levels ( 32327693) Platelet count ( 27863252) Plateletcrit ( 27863252) Triglycerides ( 24507774 30275531)
Interacting Genes		13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A	23 interacting genes: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 RAPGEF3 RAPGEF4 RHOB SPP1 TUBA4A TUBB UPF2
Entrez ID		11069	4130
HPRD ID		06929	02549
Ensembl ID		ENSG00000091428	ENSG00000166963
Uniprot IDs		B7Z278 Q8WZA2	P78559 Q504X9
PDB IDs
Enriched GO Terms of Interacting Partners?
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