CELF2 and PTGS2

Data Source:
BioGRID (unspecified method)

		CELF2	PTGS2
Description		CUGBP Elav-like family member 2	prostaglandin-endoperoxide synthase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Flemming Body Ribonucleoprotein Complex	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Pre-mRNA Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Selection RNA Processing Regulation Of Heart Contraction	Prostaglandin Biosynthetic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response
Pathways			Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases			Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Allergic rhinitis ( 30013184) Asthma ( 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Body size at age 10 ( 32376654) Breastfeeding duration ( 25475840) Chronic kidney disease ( 31015462) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Liver enzyme levels (alanine transaminase) ( 24124411) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean platelet volume ( 32888494) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Response to lamotrigine in genetic generalized epilepsy ( 32308125) Urinary albumin-to-creatinine ratio ( 26631737)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		21 interacting genes: A1CF APOBEC1 APP ELAVL1 MIR140 MIR155 MIR18B MIR199A1 MIR19A MIR19B1 MIR205 MIR21 MIR29C MIR34B MIR363 MIR7-1 MIR9-2 MIRLET7I PCBP1 PTGS2 TRAF3	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		10659	5743
HPRD ID		03964	02599
Ensembl ID		ENSG00000048740	ENSG00000073756
Uniprot IDs		A0A0J9YX66 A0A0J9YXJ0 A0A1B0GU44 A0A1B0GUN8 B4DDE7 B4DIB6 B4DT00 B4DZ01 E9PC62 O95319	P35354
PDB IDs		2MY7 2MY8 4LJM 4LMZ 4TLQ 5M8I	1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?
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