TMEM147 and TACR1

Data Source:
BioGRID (two hybrid)

		TMEM147	TACR1
Description		transmembrane protein 147	tachykinin receptor 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Protein Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process		Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS			Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		54 interacting genes: ABHD16A ABI3 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		10430	6869
HPRD ID		17633	01208
Ensembl ID		ENSG00000105677	ENSG00000115353
Uniprot IDs		Q9BVK8	P25103
PDB IDs		6W6L	2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP
Enriched GO Terms of Interacting Partners?
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