TMEM147 and SLC22A1

Data Source:
BioGRID (protein complementation assay)

		TMEM147	SLC22A1
Description		transmembrane protein 147	solute carrier family 22 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Presynapse
	Molecular Function	Protein Binding	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity
	Biological Process		Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Dopamine Uptake Cation Transmembrane Transport Transport Across Blood-brain Barrier Acetate Ester Transport Toxin Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways			Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 26034056 21743057) Serum metabolite levels ( 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995)
Interacting Genes		54 interacting genes: ABHD16A ABI3 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	27 interacting genes: ALDOA CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM KRTCAP2 LAPTM4A LAPTM4B MUC1 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB
Entrez ID		10430	6580
HPRD ID		17633	04007
Ensembl ID		ENSG00000105677	ENSG00000175003
Uniprot IDs		Q9BVK8	O15245
PDB IDs		6W6L
Enriched GO Terms of Interacting Partners?
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