PGRMC2 and C5

Data Source:
BioGRID (two hybrid)

		PGRMC2	C5
Description		progesterone receptor membrane component 2	complement C5
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endomembrane System Membrane Integral Component Of Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Steroid Hormone Receptor Activity Steroid Binding Protein Binding Heme Transmembrane Transporter Activity Heme Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Heme Transport Steroid Hormone Mediated Signaling Pathway Adipose Tissue Development	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis
Pathways			Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs			Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Bone mineral density (total hip) ( 29883787)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		57 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LPAR3 MALL MFHAS1 MFSD5 ORMDL1 PEDS1-UBE2V1 PEX16 PGRMC1 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VAPA VEZT YIPF2 ZDHHC21 ZFPL1	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		10424	727
HPRD ID		09665	00405
Ensembl ID		ENSG00000164040	ENSG00000106804
Uniprot IDs		O15173	P01031 Q59GS8
PDB IDs			1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?