PGRMC2 and SLC30A8

Data Source:
BioGRID (two hybrid)

		PGRMC2	SLC30A8
Description		progesterone receptor membrane component 2	solute carrier family 30 member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endomembrane System Membrane Integral Component Of Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle
	Molecular Function	Steroid Hormone Receptor Activity Steroid Binding Protein Binding Heme Transmembrane Transporter Activity Heme Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Heme Transport Steroid Hormone Mediated Signaling Pathway Adipose Tissue Development	Zinc Ion Transport Cellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Secretion Positive Regulation Of Insulin Secretion Sequestering Of Zinc Ion Response To Interferon-gamma Glucose Homeostasis Regulation Of Vesicle-mediated Transport Regulation Of Sequestering Of Zinc Ion Response To Interleukin-1 Zinc Ion Transmembrane Transport
Pathways			Insulin processing Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases			Type II diabetes mellitus
GWAS		Bone mineral density (total hip) ( 29883787)	Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting plasma glucose ( 25187374 28270201) Glycated hemoglobin levels ( 24647736 19096518 28898252) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 27189021 22885922 24509480 17293876 30054458 22693455 26961502 29358691 30297969 19734900 29632382 26818947 31217584 23945395 31118516 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590 17460697 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)
Interacting Genes		57 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LPAR3 MALL MFHAS1 MFSD5 ORMDL1 PEDS1-UBE2V1 PEX16 PGRMC1 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VAPA VEZT YIPF2 ZDHHC21 ZFPL1	70 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27
Entrez ID		10424	169026
HPRD ID		09665	15370
Ensembl ID		ENSG00000164040	ENSG00000164756
Uniprot IDs		O15173	Q8IWU4
PDB IDs			6XPD 6XPE 6XPF
Enriched GO Terms of Interacting Partners?
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