STUB1 and RUNX2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		STUB1	RUNX2
Description		STIP1 homology and U-box containing protein 1	RUNX family transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly	Ossification Osteoblast Differentiation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Hemopoiesis Neuron Differentiation BMP Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Cleidocranial dysplasia
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 25429064 18391951) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		126 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CASP6 CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RGS17 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP	37 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1
Entrez ID		10273	860
HPRD ID		06232	02566
Ensembl ID		ENSG00000103266	ENSG00000124813
Uniprot IDs		Q9UNE7	A0A0D9SEN7 Q13950 Q32MY8
PDB IDs		4KBQ 6EFK 6NSV
Enriched GO Terms of Interacting Partners?
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