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STUB1 and CFTR
Data Source:
BioGRID
(enzymatic study)
STUB1
CFTR
Description
STIP1 homology and U-box containing protein 1
CF transmembrane conductance regulator
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Chaperone Complex
Nucleus
Cytoplasm
Lysosomal Membrane
Early Endosome
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Golgi-associated Vesicle Membrane
Clathrin-coated Vesicle Membrane
Early Endosome Membrane
Protein-containing Complex
Chloride Channel Complex
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
Chloride Channel Activity
Intracellularly ATP-gated Chloride Channel Activity
Protein Binding
ATP Binding
Bicarbonate Transmembrane Transporter Activity
Chloride Transmembrane Transporter Activity
Isomerase Activity
ATPase Activity
Chloride Channel Regulator Activity
Chloride Channel Inhibitor Activity
Enzyme Binding
PDZ Domain Binding
ATPase-coupled Transmembrane Transporter Activity
Chaperone Binding
Sec61 Translocon Complex Binding
Biological Process
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Heat
ERBB2 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein Maturation
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Cholesterol Biosynthetic Process
Vesicle Docking Involved In Exocytosis
Bicarbonate Transport
Protein Deubiquitination
Cholesterol Transport
Response To Endoplasmic Reticulum Stress
Transepithelial Water Transport
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Exocytosis
Sperm Capacitation
Multicellular Organismal Water Homeostasis
Intracellular PH Elevation
Transmembrane Transport
Membrane Hyperpolarization
Membrane Organization
Cellular Response To CAMP
Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity
Chloride Transmembrane Transport
Positive Regulation Of Voltage-gated Chloride Channel Activity
Cellular Response To Forskolin
Pathways
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
ABC-family proteins mediated transport
RHO GTPases regulate CFTR trafficking
Defective CFTR causes cystic fibrosis
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
ATP
Bumetanide
Glyburide
Ibuprofen
Colforsin
Phosphoaminophosphonic Acid-Adenylate Ester
Dexfosfoserine
Crofelemer
Lonidamine
Ivacaftor
Dexibuprofen
Lumacaftor
Tezacaftor
Elexacaftor
Diseases
Cystic fibrosis (CF)
Hereditary pancreatitis; Hereditary chronic pancreatitis
Congenital bilateral absence of vas deferens
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Barrett's esophagus or Esophageal adenocarcinoma (
27527254
)
Glaucoma (
30054594
)
Gout (
22179738
)
Response to methotrexate in juvenile idiopathic arthritis (
24709693
)
Response to platinum-based chemotherapy in non-small-cell lung cancer (
22872573
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
126 interacting genes:
ABL1
ACD
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BCR
BMPR1B
CASP6
CCL28
CDK4
CDKN1A
CFTR
CIP2A
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FOXP3
GHR
GPR37
GUCY1A1
GUCY1A2
HIF1A
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
INSR
JOSD1
JOSD2
KHDRBS1
LRRK1
LRRK2
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
PA2G4
PFN1
PLK1
POLB
POT1
POU5F1
PPARG
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PRMT5
PSMA3
PSMD4
PTEN
RAF1
RGS17
RHBDF2
RUNX2
RUSC1
S100A2
S100P
SIRT6
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TPD52
TRAF6
TXN2
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
VCP
XIAP
29 interacting genes:
CANX
CLCN3
DERL1
DNAJA1
DNAJC5
EZR
GOPC
HSP90AA1
MARCHF2
NHS
PDZD3
PDZK1
PPP2R1B
PRKAA1
PRKACA
PRKAR2A
PRKCA
PRKCE
PRKG1
RNF5
SLC4A7
SLC4A8
SLC9A3R1
SLC9A3R2
SLC9A6
SNAP23
STUB1
STX1A
UBE2I
Entrez ID
10273
1080
HPRD ID
06232
03883
Ensembl ID
ENSG00000103266
ENSG00000001626
Uniprot IDs
Q9UNE7
A0A024R730
P13569
PDB IDs
4KBQ
6EFK
6NSV
1NBD
1XMI
1XMJ
2BBO
2BBS
2BBT
2LOB
2PZE
2PZF
2PZG
3GD7
3ISW
4WZ6
5D2D
5D3E
5D3F
5TF7
5TF8
5TFA
5TFB
5TFC
5TFD
5TFF
5TFG
5TFI
5TFJ
5TGK
5UAK
6GJQ
6GJS
6GJU
6GK4
6GKD
6HEP
6MSM
6O1V
6O2P
6UK1
Enriched GO Terms of Interacting Partners
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